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Rubicon negatively regulates maturation and fusion of the autophagosome with the lysosome and endocytic trafficking by suppressing VPS34 kinase activity (151153)

Starting with 1 mg daily for the first week, then adjusting based on tolerance and initial response, provides a conservative approach

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This schedule uses the largest practical dilution (3.0 mL) to keep perinjection units in a comfortable range for accurate measurement